This is the most sensitive and specific blood test for celiac disease, an autoimmune disorder characterized by an inappropriate immune response to gluten, and related dietary proteins in rye and barley.
Celiac disease tests are ordered when someone has signs and symptoms suggesting celiac disease, malnutrition, and/or malabsorption. Symptoms are often nonspecific and variable, making the disease difficult to spot. The symptoms may, for a time, be mild and go unnoticed and then progressively worsen or occur sporadically. The condition can affect different parts of the body.
One or more antibody tests may be ordered when someone with celiac disease has been on a gluten-free diet for a period of time. This is done to verify that antibody levels have decreased and to verify that the diet has been effective in reversing the intestinal lining damage (this is sometimes still confirmed with a second biopsy).
Fasting Required: No; for diagnosis, you should continue to eat foods that contain gluten for a time period, such as several weeks, prior to testing; for monitoring, no preparation is necessary.
CPT Code: 83516
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